Researchers are doing a study with adults with chronic (greater than or about 1 yr) paralysis due to spinal cord injury or disorder (SCI/D). This study is a survey being conducted to understand changes in spasticity (variable and involuntary muscle contractions) that occur in people with SCI/D. We are specifically interested in spasticity after taking in substances commonly known as “psychedelics”.
“Classic” psychedelics—💠 lysergic acid diethylamide (LDS), 🍄 psilocybin, 🌫️ dimethyltryptamine (DMT), and 🌵 mescaline—are psychoactive substances that act on many different areas of the nervous system. These substances are noted for their impact on perception and consciousness. However, some new studies have shown that these substances also alter nerve signals traveling from the spine to the muscles (i.e., “motor nerves”). Because spasticity in people with SCI/D is a measure of motor nerve excitability, knowledge about changes in spasticity while on psychedelics can be used to understand the impact of these substances on motor nerves.